The State Food and Drug Administration of China (SFDA) has received several reports of adverse reactions to Zhi xue capsule in recent years [7A, 8S]. Conclusions: Boils, fungal infections, scabies caused by skin parasites (mites), skin lesions, oozing sores and genital itching can be treated effectively with a topical poultice of Ku Shen. 2020 Sep 13;2020:5267684. doi: 10.1155/2020/5267684. Atopic eczema is thought to be a hereditary condition, being genetically linked. 4). A series of synthetic isoflavones have also been shown to act as modulators at recombinant GABAA receptors. The table on the right provides the docking energies for tofogliflozin, the Food and Drug administration (FDA)-approved SGLT2 inhibitors (dapagliflozin and canagliflozin), and major fenugreek C-glycosides (vitexin, orientin, and vicenin). It has a medicinal history of more than 2,000 years. It is indicated in copulation pain due to formation of Damp-Heat resulting from weakness of the Spleen. In this study the herb-drug interactions between S. flavescens and indinavir, a protease inhibitor for HIV treatment, were evaluated in rats. The dried root of sophora flavescens is a major herb used in the traditional Chinese medicine (CTM) for hundreds of years where it is known as Ku Shen (苦参). Sophora flavescens has shown anticancer effects in lab studies, but has not been studied for cancer prevention or treatment in humans. Sophora flavescens, the shrubby sophora, is a species of plant in the genus Sophora of the family Fabaceae. Sophora angustifolia root extract is one of the three major plant soothing agents for skin care (the other two are licorice extract and astragalus extract). This plant often grows on hillsides, grass slopes, or … 4), act as negative modulators of GABAC receptors containing ρ-subunits (Goutman, Waxemberg, Donate-Oliver, Pomata, & Calvo, 2003). The anticancer and anti-infection abilities of these components are especially attractive areas for research. This formula is mainly indicated in downward flow of Damp-Heat. Sophora Root (ku shen) What is sophora? Sophora enters into the composition of creams and ointments used as regenerating, antiflogistic means for the treatment of psoriasis, eczema, lupus erythematosus, etc. An ethnoveterinary study on medicinal plants used by the Buyi people in Southwest Guizhou, China. The aim of this review is to provide updated and comprehensive information regarding the botany, ethnopharmacology, phytochemistry, biological activities and toxicology of Sophora flavescens and to discuss possible trends and opportunities for further research on Sophora flavescens. The root is used. Sophora Root. Long Dan Xie Gan Wan Gentiaria Draining the Liver Pill. A herbal record lists the following adverse effects of Ku shen: salivation, abnormal gait, dyspnea, tachycardia [85]. Also Known As - sophora flavescens radix, lightyellow sophora root, Flavescent Sophora Root, Root of Light Yellow Sophora, Sophora Flavescens Root Overview - Though literally translated as bitter ginseng in English, Ku Shen has nothing to do with ginseng at all. After withdrawal and symptomatic treatment, there was full recovery in eight cases, and the rest improved markedly. An herbal medicine, kushen, is obtained from the roots of Sophora japonica (Sophora flavescens) and is used as an anti-inflammatory and bitter-tasting stomachic. Long Dan Cao Radix Gentianae 5g, Huang Lian Rhizoma Coptidis 5g, She Chuang Zi Fructus Cnidii 10g, Chi Shao Yao Radix Paeoniae Rubrae 10g and Pu Gong Ying Herba Taraxaci 10g, etc., should be added to clear the Heat, eliminate Damp and relieve the pain. In TCM : Sophora Flavescens Root : Ku Shen Jian Meridians associated : Heart, Urinary Bladder, Liver, Small Intestine and Large Intestine. Sophora flavescens contains flavonoids and alkaloids. The actions of both compounds were flumazenil-insensitive. The flavonoids salvigenin, cirsimaritin, and hispidulin acted as positive modulators when applied in the presence of low concentrations of GABA, but in the presence of high concentrations of GABA acted as negative modulators, demonstrating a biphasic action. An herbal medicine, kushen, is obtained from the roots of Sophora japonica (Sophora flavescens) and is used as an anti-inflammatory and bitter-tasting stomachic.The principal component of kushen is the piperidine alkaloid matrine. Sophora flavescens, (Kurara) belongs to the family Leguminosae and is distributed in Mongolia, the eastern part of Russia, China, Korea, and Japan. Change Yellow (Discharge) Decoction. Many natural flavonoids have been identified as influencing ionotropic GABA receptors through bioassay-guided fractionation of plant extracts (Fig. Sophora flavescens Ait. Radix Sophorae Flavescentis is a traditional Chinese medicine, which is the roots of Sophora flavescens and is used to treat abscess, dysentery, eczema and skin itch. It is commonly used for the treatment of viral hepatitis, enteritis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases (such as colpitis, psoriasis and eczema). 2020 Aug 17;16(1):46. doi: 10.1186/s13002-020-00396-y. Alkaloids; Antimicrobial activity; Antitumor activity; Ethnopharmacology; Flavonoids; Sophora flavescens. The species is hermaphrodite (has both male and female organs) and is pollinated by Insects. It can fix Nitrogen. Salvia triloba, traditionally known as Greek sage on bioassay-guided fractionation yielded a variety of flavonoids and terpenoids as modulators (Abdelhalim, Chebib, Aburjai, Johnston, & Hanrahan, 2004) (Fig. It has a good treatment of eczema and dermatitis, and can alleviate skin itching caused by inflammation. Front. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. A mouse study indicated that oxymatrine has hepatoprotective activity against acute liver injury induced by allyl alcohol (Liu et al., 1994). Epub 2016 Apr 13. The actual smell and taste. Johnston, in Advances in Pharmacology, 2015. Readers are directed to excellent review articles on this topic.29,30 Many of these molecules are well-known flavanoid glycosides and alkaloids already characterized for their antioxidant properties. Sophora flavescens is a deciduous shrub related to peas. Harvest. Eczema is characterized by itchy, dry, rough, flakey, inflamed, and irritated skin.  |  Extracts are taken either orally or by injection. ; 16 ( 1 ):272. doi: 10.1186/s12866-020-01956-8 in Comprehensive natural reported! ; flavonoids ; Sophora flavescens plant 1994 ) Director, Institute for traditional,. Has been considered a valuable resource in both traditional and modern medicine evergreen member of the genus.. 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